ZFIN is now using GRCz12tu for Genomic Data
Gene
ctnna1
- ID
- ZDB-GENE-991207-24
- Name
- catenin alpha 1
- Symbol
- ctnna1 Nomenclature History
- Previous Names
-
- ctnna
- dan[a]E
- [a]E-catenin (1)
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables actin filament binding activity and cadherin binding activity. Involved in adherens junction maintenance and chordate embryonic development. Acts upstream of or within tissue homeostasis. Located in several cellular components, including adherens junction; cell cortex; and microvillus. Part of catenin complex. Is expressed in DEL. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76830 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| patterned macular dystrophy 2 | Alliance | Macular dystrophy, patterned, 2 | 608970 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-catenin | Alpha-catenin/vinculin-like superfamily | Vinculin/alpha-catenin | Vinculin, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q9PVF8 | InterPro | 907 | ||||
| UniProtKB:A0AC58H5J5 | InterPro | 623 | ||||
| UniProtKB:A0AC58H5J6 | InterPro | 746 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctnna1-201
(1)
|
Ensembl | 3,734 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers