Gene
zp2.1
- ID
- ZDB-GENE-991129-5
- Name
- zona pellucida glycoprotein 2, tandem duplicate 1
- Symbol
- zp2.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to be active in collagen-containing extracellular matrix and egg coat. Is expressed in oocyte; ovarian follicle stage I; ovarian follicle stage II; and ovary.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11126 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1505D6 | ZFIN Curated Data | |
| Encodes | EST | fa12e07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152728 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158209 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173435 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191906 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC124100 (1) | 1370 nt | ||
| Genomic | GenBank:CU914156 | 42468 nt | ||
| Polypeptide | GenPept:AAI24101 (1) | 431 aa |
No data available
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Wu, T., Cheng, Y., Liu, Z., Tao, W., Zheng, S., Wang, D. (2018) Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Fish physiology and biochemistry. 44(2):435-449
- Zhu, B., Pardeshi, L., Chen, Y., Ge, W. (2018) Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish. Frontiers in endocrinology. 9:593
- Dambal, V.Y., Selvan, K.P., Lite, C., Barathi, S., Santosh, W. (2017) Developmental toxicity and induction of vitellogenin in embryo-larval stages of zebrafish (Danio rerio) exposed to methyl Paraben. Ecotoxicology and environmental safety. 141:113-118
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
- Liu, C., Deng, J., Yu, L., Ramesh, M., and Zhou, B. (2010) Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquatic toxicology (Amsterdam, Netherlands). 96(1):70-76
- Mold, D.E., Dinitz, A.E., and Sambandan, D.R. (2009) Regulation of Zebrafish Zona Pellucida Gene Activity in Developing Oocytes. Biology of reproduction. 81(1):101-110
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