Gene

glra1

ID
ZDB-GENE-991117-1
Name
glycine receptor, alpha 1
Symbol
glra1 Nomenclature History
Previous Names
  • [a]Z1 (1)
  • GlyR [a]Z1 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits extracellularly glycine-gated chloride channel activity and glycine binding activity. Is predicted to contribute to chloride channel activity. Involved in several processes, including central nervous system development; regulation of neuron differentiation; and response to amino acid. Localizes to integral component of membrane. Is expressed in brain; hindbrain; and spinal cord. Used to study hyperekplexia. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glra1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperekplexia 1 Alliance Hyperekplexia 1 149400
Associated With glra1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
Family IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Family IPR006201 Neurotransmitter-gated ion-channel
Family IPR008127 Glycine receptor alpha
Family IPR008128 Glycine receptor alpha1
Homologous_superfamily IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Domain Details Per Protein
Protein Length Gamma-aminobutyric acid A receptor/Glycine receptor alpha Glycine receptor alpha Glycine receptor alpha1 Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily
UniProtKB:B3DHZ5 444
UniProtKB:Q8QG93 459
UniProtKB:E9QC31 457
UniProtKB:G1K2K7 459
UniProtKB:A0A0B5JQ36 245
UniProtKB:O93430 444
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations