Gene

igf2a

ID
ZDB-GENE-991111-3
Name
insulin-like growth factor 2a
Symbol
igf2a Nomenclature History
Previous Names
  • IGF-II (1)
  • igf2 (1)
  • igf2b (1)
  • etID31232.25 (1)
  • wu:fc26e03
  • zgc:91781
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables insulin-like growth factor receptor binding activity. Acts upstream of or within notochord development; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; head; notochord; and ovary. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
29 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With igf2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Silver-Russell syndrome 3 616489
Associated With igf2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR013576 Insulin-like growth factor II E-peptide, C-terminal
Domain IPR016179 Insulin-like
Family IPR022334 Insulin-like growth factor II
Family IPR022350 Insulin-like growth factor
Family IPR022352 Insulin family
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin, conserved site Insulin family Insulin-like Insulin-like growth factor Insulin-like growth factor II Insulin-like growth factor II E-peptide, C-terminal Insulin-like superfamily
UniProtKB:Q8UUI9 197
UniProtKB:Q9PUD0 197
UniProtKB:Q5U3B4 197
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations