Gene
igf2a
- ID
- ZDB-GENE-991111-3
- Name
- insulin-like growth factor 2a
- Symbol
- igf2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables insulin-like growth factor receptor binding activity. Acts upstream of or within notochord development; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; female organism; musculature system; and notochord. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-igf2a | Zebrafish Nomenclature Committee | |
CRISPR2-igf2a | (2) | |
CRISPR3-igf2a | Weiss et al., 2022 | |
MO1-igf2a | N/A | (3) |
MO2-igf2a | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Silver-Russell syndrome 3 | 616489 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Insulin, conserved site | Insulin-like | Insulin-like growth factor II | Insulin-like growth factor II E-peptide, C-terminal | Insulin-like superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q9PUD0 | InterPro | 197 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-69P21 | ZFIN Curated Data | |
Encodes | EST | fc26e03 | ||
Encodes | cDNA | MGC:91781 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131433 (1) | 2051 nt | ||
Genomic | GenBank:AL928880 (2) | 98850 nt | ||
Polypeptide | UniProtKB:Q9PUD0 (1) | 197 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243
- de Alba, G., Carrillo, S., Sánchez-Vázquez, F.J., López-Olmeda, J.F. (2022) Combined blue light and daily thermocycles enhance zebrafish growth and development. Journal of experimental zoology. Part A, Ecological and integrative physiology. 337(5):501-515
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Kasica, N., Święch, A., Saładziak, K., Mackiewicz, J., Osęka, M. (2022) The Inhibitory Effect of Selected D2 Dopaminergic Receptor Agonists on VEGF-Dependent Neovascularization in Zebrafish Larvae: Potential New Therapy in Ophthalmic Diseases. Cells. 11(7):
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