Gene
igf2a
- ID
- ZDB-GENE-991111-3
- Name
- insulin-like growth factor 2a
- Symbol
- igf2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables insulin-like growth factor receptor binding activity. Acts upstream of or within notochord development; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; head; notochord; and ovary. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Silver-Russell syndrome 3 | 616489 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR022353 | Insulin, conserved site |
| Domain | IPR013576 | Insulin-like growth factor II E-peptide, C-terminal |
| Domain | IPR016179 | Insulin-like |
| Family | IPR022334 | Insulin-like growth factor II |
| Family | IPR022350 | Insulin-like growth factor |
| Family | IPR022352 | Insulin family |
| Homologous_superfamily | IPR036438 | Insulin-like superfamily |
Domain Details Per Protein
| Protein | Length | Insulin, conserved site | Insulin family | Insulin-like | Insulin-like growth factor | Insulin-like growth factor II | Insulin-like growth factor II E-peptide, C-terminal | Insulin-like superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9PUD0
|
197 |
Interactions and Pathways
No data available
Plasmids
No data available