Gene

igf2a

ID
ZDB-GENE-991111-3
Name
insulin-like growth factor 2a
Symbol
igf2a Nomenclature History
Previous Names
  • IGF-II (1)
  • igf2 (1)
  • igf2b (1)
  • etID31232.25 (1)
  • wu:fc26e03
  • zgc:91781
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables insulin-like growth factor receptor binding activity. Acts upstream of or within notochord development; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; female organism; musculature system; and notochord. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
38 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb148Allele with one deletionUnknownUnknownCRISPR
ihb149Allele with one deletionUnknownUnknownCRISPR
umo76Allele with one deletionUnknownPremature StopCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With igf2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Silver-Russell syndrome 3 616489
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Associated With igf2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR013576 Insulin-like growth factor II E-peptide, C-terminal
Domain IPR016179 Insulin-like
Family IPR022334 Insulin-like growth factor II
Homologous_superfamily IPR036438 Insulin-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Insulin, conserved site Insulin-like Insulin-like growth factor II Insulin-like growth factor II E-peptide, C-terminal Insulin-like superfamily
UniProtKB:Q9PUD0 InterPro 197
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA igf2a-201 (1) Ensembl 2,039 nt
ncRNA igf2a-002 (1) Ensembl 520 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-69P21ZFIN Curated Data
EncodesESTfc26e03
EncodescDNAMGC:91781ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIGF211
Amino acid sequence comparison (4)
Conserved genome location (synteny) (4)
MouseIgf27
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 117
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