Gene

ppm1ab

ID

ZDB-GENE-991102-14

Name

protein phosphatase, Mg2+/Mn2+ dependent, 1Ab

Symbol

ppm1ab Nomenclature History

Previous Names

pp2ca1
wu:fd42g12
zgc:153820

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; peptidyl-threonine dephosphorylation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1083 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppm1ab Human Ortholog

No data available

Associated With ppm1ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000222	PPM-type phosphatase, divalent cation binding
Domain	IPR001932	PPM-type phosphatase-like domain
Domain	IPR012911	Protein serine/threonine phosphatase 2C, C-terminal
Family	IPR015655	Protein phosphatase 2C
Homologous_superfamily	IPR036457	PPM-type phosphatase-like domain superfamily