ZFIN ID: ZDB-GENE-991019-6
Gene Name: arylalkylamine N-acetyltransferase 2
Gene Symbol: aanat2    Nomenclature History

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Previous Names: AA-NAT (1), zfaanat2 (1), serotonin N-acetyltransferase-2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits acetyltransferase activity. Involved in several processes, including neutrophil chemotaxis; photoperiodism; and positive regulation of circadian sleep/wake cycle, sleep. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Is expressed in brain; ovary; and retina. Orthologous to human AANAT (aralkylamine N-acetyltransferase).
Genome Resources: Alliance (1),  Gene:30685 (1),  Ensembl(GRCz11):ENSDARG00000079802 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct801 Small Deletion Unknown Unknown TALEN
sus013 Indel Exon 1 Frameshift CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-aanat2 1
TALEN1-aanat2 1
DISEASE ASSOCIATED WITH aanat2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH aanat2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process circadian rhythm (more)
Cellular Component cytoplasm (more)
Molecular Function acetyltransferase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000182 GNAT domain
Homologous_superfamily IPR016181 Acyl-CoA N-acyltransferase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA aanat2-201 (1)    Ensembl 1446
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM aanat2
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(aanat2:CFP-NTR) aanat2 CFPNTR Danio rerio 1 2
Tg(aanat2:EGFP) aanat2 EGFP Danio rerio 3 23
Tg(aanat2:EGFP-2A-Dclocka-5xMYC) aanat2 2AclockaEGFPMYC Danio rerio 1 3
Tg(aanat2:mRFP) aanat2 mRFP Danio rerio 1 3
MARKER RELATIONSHIPS
aanat2 Contained in: [BAC] CH211-155C19 (1), CH211-233G21 (1), DKEY-189N21 (1) (order this)
aanat2 Encodes: [cDNA] MGC:73039 (1), MGC:86582 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131411 (1) 1131 bp
Genomic GenBank:AL928800 153880 bp
Select Tool
Polypeptide UniProtKB:Q9PVD7 (1) 209 aa
Sequence Information (all 21)
ORTHOLOGY for aanat2 ( Chr: 3 )
CITATIONS (83)