ZFIN is now using GRCz12tu for Genomic Data
Gene
skia
- ID
- ZDB-GENE-990715-9
- Name
- v-ski avian sarcoma viral oncogene homolog a
- Symbol
- skia Nomenclature History
- Previous Names
-
- skiA
- id:ibd1250
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within cardiac conduction; cartilage development; and regionalization. Located in nucleus. Is expressed in several structures, including brain; lens; presumptive diencephalon; solid lens vesicle; and tail bud. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157999 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Doyle et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis | Alliance | Shprintzen-Goldberg syndrome | 182212 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| craniosynostosis | WT + MO2-skia | standard conditions | Doyle et al., 2012 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003380 | SKI/SNO/DAC domain |
| Domain | IPR014890 | c-SKI SMAD4-binding domain |
| Domain | IPR047315 | Ski oncogene-like, Dachshund-homology domain |
| Family | IPR023216 | Transcription regulator SKI/SnoN |
| Homologous_superfamily | IPR009061 | Putative DNA-binding domain superfamily |
| Homologous_superfamily | IPR010919 | SAND-like domain superfamily |
| Homologous_superfamily | IPR037000 | Ski-like, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | c-SKI SMAD4-binding domain | Putative DNA-binding domain superfamily | SAND-like domain superfamily | Ski-like, DNA-binding domain superfamily | Ski oncogene-like, Dachshund-homology domain | SKI/SNO/DAC domain | Transcription regulator SKI/SnoN |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1ECW8 | InterPro | 727 | |||||||
| UniProtKB:A0A8N1Z0K9 | InterPro | 727 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers