Gene

dhh

ID
ZDB-GENE-990714-5
Name
desert hedgehog signaling molecule
Symbol
dhh Nomenclature History
Previous Names
  • sb:eu600
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and patched binding activity. Predicted to be involved in cell fate specification; regulation of gene expression; and smoothened signaling pathway. Predicted to act upstream of or within cell-cell signaling; intein-mediated protein splicing; and protein autoprocessing. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in testis. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dhh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46,XY sex reversal Alliance 46XY gonadal dysgenesis with minifascicular neuropathy 607080
46,XY sex reversal 7 Alliance 46XY sex reversal 7 233420
Associated With dhh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000320 Hedgehog, N-terminal signalling domain
Domain IPR001767 Hedgehog protein, Hint domain
Domain IPR003586 Hint domain C-terminal
Domain IPR003587 Hint domain N-terminal
Family IPR001657 Hedgehog protein
Homologous_superfamily IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Homologous_superfamily IPR036844 Hint domain superfamily
PTM IPR006141 Intein N-terminal splicing region
Domain Details Per Protein
Protein Length Hedgehog, N-terminal signalling domain Hedgehog protein Hedgehog protein, Hint domain Hedgehog signalling/DD-peptidase zinc-binding domain superfamily Hint domain C-terminal Hint domain N-terminal Hint domain superfamily Intein N-terminal splicing region
UniProtKB:E9QGT4 63
UniProtKB:Q4PLX3 447
UniProtKB:B3DJ46 447
UniProtKB:P79729 88
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations