ZFIN is now using GRCz12tu for Genomic Data
Gene
dhh
- ID
- ZDB-GENE-990714-5
- Name
- desert hedgehog signaling molecule
- Symbol
- dhh Nomenclature History
- Previous Names
-
- sb:eu600
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable morphogen activity. Predicted to be involved in smoothened signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular region. Is expressed in testis. Human ortholog(s) of this gene implicated in 46,XY complete gonadal dysgenesis; 46,XY gonadal dysgenesis with minifascicular neuropathy; and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu600 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY gonadal dysgenesis with minifascicular neuropathy | Alliance | 46XY gonadal dysgenesis with minifascicular neuropathy | 607080 |
| 46,XY sex reversal 7 | Alliance | 46XY sex reversal 7 | 233420 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000320 | Hedgehog, N-terminal signalling domain |
| Domain | IPR001767 | Hedgehog protein, Hint domain |
| Domain | IPR003586 | Hint domain C-terminal |
| Domain | IPR003587 | Hint domain N-terminal |
| Family | IPR001657 | Hedgehog protein |
| Family | IPR050387 | Hedgehog Signaling |
| Homologous_superfamily | IPR009045 | Peptidase M74/Hedgehog-like, zinc-binding domain superfamily |
| Homologous_superfamily | IPR036844 | Hint domain superfamily |
| PTM | IPR006141 | Intein N-terminal splicing region |
Domain Details Per Protein
| Protein | Additional Resources | Length | Hedgehog, N-terminal signalling domain | Hedgehog protein | Hedgehog protein, Hint domain | Hedgehog Signaling | Hint domain C-terminal | Hint domain N-terminal | Hint domain superfamily | Intein N-terminal splicing region | Peptidase M74/Hedgehog-like, zinc-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NTL6 | InterPro | 447 | |||||||||
| UniProtKB:P79729 | InterPro | 88 | |||||||||
| UniProtKB:Q4PLX3 | InterPro | 447 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers