ZFIN is now using GRCz12tu for Genomic Data
Gene
wif1
- ID
- ZDB-GENE-990712-17
- Name
- wnt inhibitory factor 1
- Symbol
- wif1 Nomenclature History
- Previous Names
-
- zgc:110507 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable signaling receptor binding activity. Acts upstream of or within habenula development; negative regulation of canonical Wnt signaling pathway; and swim bladder development. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including anterior swim bladder bud; nervous system; paraxial mesoderm; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (Wnt inhibitory factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu316 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR003306 | WIF domain |
| Domain | IPR057138 | Platelet endothelial aggregation receptor 1-like, EGF domain |
| Family | IPR013309 | Wnt inhibitory factor (WIF)-1 |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR038677 | WIF domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like, conserved site | EGF-like domain | Growth factor receptor cysteine-rich domain superfamily | Platelet endothelial aggregation receptor 1-like, EGF domain | WIF domain | WIF domain superfamily | Wnt inhibitory factor (WIF)-1 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6F9 | InterPro | 378 | |||||||
| UniProtKB:A0AB32TRY8 | InterPro | 346 | |||||||
| UniProtKB:A0AC58J5E7 | InterPro | 331 | |||||||
| UniProtKB:A0ACK5Z1Z0 | InterPro | 378 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers