Gene

ucp2

ID
ZDB-GENE-990708-8
Name
uncoupling protein 2
Symbol
ucp2 Nomenclature History
Previous Names
  • zUCP2 (1)
  • cb74 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Is predicted to enable oxidative phosphorylation uncoupler activity. Involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Acts upstream of or within mitochondrial transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ucp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Obesity, susceptibility to, BMIQ4} 607447
Associated With ucp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002030 Mitochondrial carrier UCP-like
Homologous_superfamily IPR023395 Mitochondrial carrier domain superfamily
Repeat IPR018108 Mitochondrial substrate/solute carrier
Domain Details Per Protein
Protein Length Mitochondrial carrier domain superfamily Mitochondrial carrier UCP-like Mitochondrial substrate/solute carrier
UniProtKB:Q9W720 310
UniProtKB:Q6P0I3 310
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations