Gene
ucp2
- ID
- ZDB-GENE-990708-8
- Name
- uncoupling protein 2
- Symbol
- ucp2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to localize to integral component of membrane and mitochondrial inner membrane. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal failure; non-alcoholic fatty liver disease; and obesity. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Orthologous to human UCP2 (uncoupling protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb74 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Obesity, susceptibility to, BMIQ4} | 607447 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mitochondrial carrier domain superfamily | Mitochondrial carrier protein | Mitochondrial Metabolite Transporter | Mitochondrial substrate/solute carrier |
|---|---|---|---|---|---|
|
UniProtKB:Q6P0I3
|
310 | ||||
|
UniProtKB:A0A8M3B6H4
|
258 | ||||
|
UniProtKB:Q9W720
|
310 |
Interactions and Pathways
No data available
Plasmids
No data available