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ZIRC
ZFIN ID: ZDB-GENE-990621-3
Gene Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Symbol: dbh    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have copper ion binding activity and dopamine beta-monooxygenase activity. Involved in sleep. Predicted to localize to the extracellular space and secretory granule membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Orthologous to human DBH (dopamine beta-hydroxylase).
Genome Resources: Alliance (1),  Gene:30505 (1),  Ensembl(GRCz11):ENSDARG00000069446 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct806 Insertion Exon 3 Premature Stop ZINC_FINGER_NUCLEASE
sa21676 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24865 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dbh
    1
    PHENOTYPE
    Data: 2 figures from Singh et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH dbh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dopamine beta-hydroxylase deficiency Alliance Orthostatic hypotension 1, due to DBH deficiency 223360
    DISEASE ASSOCIATED WITH dbh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sleep (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dbh-201 (1)    Ensembl 1953
    ncRNA dbh-002 (1)    Ensembl 858
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dbh
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(dbh:EGFP) dbh EGFP Danio rerio 4 12
    Tg(dbh:EGFP-Hsa.MYCN) dbh EGFP Danio rerioHomo sapiens 1 12
    Tg(dbh:GAL4FF) dbh GAL4FF Danio rerio 1 3
    Tg(dbh:Hsa.ALK_F1174L) dbh Danio rerioHomo sapiens 1 4
    Tg(dbh:Hsa.DIEXF) dbh Danio rerioHomo sapiens 2 1
    Tg(dbh:Hsa.LMO1) dbh Danio rerioHomo sapiens 1 1
    Tg(dbh:Hsa.MYCN) dbh Danio rerioHomo sapiens 1 1
    Tg(dbh:Hsa.NF1) dbh Danio rerioHomo sapiens 1 1
    Tg(dbh:Hsa.NF1_R1276P) dbh Danio rerioHomo sapiens 1 1
    Tg(dbh:mCherry) dbh mCherry Danio rerio 3 5
    Tg(dbh:Mmu.Gab2) dbh Danio rerioMus musculus 1 1
    Tg(dbh:Mmu.Gab2,dbh:EGFP) dbh EGFP Danio rerioMus musculus 0 1
    Tg(dbh:ptpn11a_E69K-EGFP) dbh EGFPptpn11a Danio rerio 1 1
    Tg2(dbh:EGFP) dbh EGFP Danio rerio 1 4
    Tg2(dbh:mCherry) dbh mCherry Danio rerio 1 2
    MARKER RELATIONSHIPS
    dbh Contained in: [BAC] CH211-270H11 (1) (order this)
    dbh Encodes: [cDNA] MGC:194632 (1) (order this), MGC:194650 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001109694 (1) 1845 bp
    Genomic GenBank:AL935290 (1) 129665 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QLP9 (1) 614 aa
    Sequence Clusters UniGene:21021 (1)
    Sequence Information (all 17)
    ORTHOLOGY for dbh ( Chr: 10 )
    CITATIONS (67)