her5

ID

ZDB-GENE-990415-90

Name

hairy-related 5

Symbol

her5 Nomenclature History

Previous Names

zgc:136537

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables protein heterodimerization activity and protein homodimerization activity. Acts upstream of or within several processes, including midbrain-hindbrain boundary development; negative regulation of neurogenesis; and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be active in nucleus. Is expressed in several structures, including EVL; brain; endoderm; neural plate; and presumptive structure. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 4. Orthologous to human HES7 (hes family bHLH transcription factor 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

52 figures from 37 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu359 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With her5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondylocostal dysostosis 4	Alliance	Spondylocostal dysostosis 4, autosomal recessive	613686

Associated With her5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003650	Orange domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR032644	Transcription factor HES-7, basic helix-loop-helix-orange domain
Family	IPR050370	Hairy and Enhancer of Split/HEY-related
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily