Gene
tle3b
- ID
- ZDB-GENE-990415-85
- Name
- TLE family member 3, transcriptional corepressor b
- Symbol
- tle3b Nomenclature History
- Previous Names
-
- fi28a02
- fj62f10
- grg3 (1)
- gro1
- gro3
- wu:fi28a02
- wu:fj62f10
- zfgro1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of or within myeloid cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; head; mesoderm; pleuroperitoneal region; and unfertilized egg. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu137 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a350 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb354 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| la025998Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13620 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17548 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20989 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34109 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40938 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40939 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tle3b | (2) | |
| CRISPR2-tle3b | Thyme et al., 2019 | |
| CRISPR3-tle3b | Thyme et al., 2019 | |
| CRISPR4-tle3b | Thyme et al., 2019 | |
| CRISPR5-tle3b | Thyme et al., 2019 | |
| MO1-tle3b | N/A | Dayyani et al., 2008 |
| MO2-tle3b | N/A | Dayyani et al., 2008 |
| MO3-tle3b | N/A | (3) |
| MO4-tle3b | N/A | Bricaud et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR005617 | Groucho/TLE, N-terminal Q-rich domain |
| Family | IPR009146 | Groucho/transducin-like enhancer |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Groucho/TLE, N-terminal Q-rich domain | Groucho/transducin-like enhancer | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B166 | InterPro | 781 | ||||||
| UniProtKB:A0A8M3AU86 | InterPro | 770 | ||||||
| UniProtKB:A0A8M3AU69 | InterPro | 782 | ||||||
| UniProtKB:A0A8M2BG40 | InterPro | 770 | ||||||
| UniProtKB:A0A8M3AU78 | InterPro | 760 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237K3 | ZFIN Curated Data | |
| Encodes | EST | eu137 | Thisse et al., 2005 | |
| Encodes | EST | fi28a02 | ||
| Encodes | EST | fj62f10 | ||
| Encodes | cDNA | MGC:193814 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131780 (1) | 2422 nt | ||
| Genomic | GenBank:AL954672 (2) | 180588 nt | ||
| Polypeptide | UniProtKB:A0A8M3AU69 (1) | 782 aa |
- Song, G., Feng, G., Li, Q., Peng, J., Ge, W., Long, Y., Cui, Z. (2024) Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish. International Journal of Molecular Sciences. 25(13):
- Haws, W., England, S., Grieb, G., Susana, G., Hernandez, S., Mirer, H., Lewis, K. (2023) Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3. Scientific Reports. 13:11511151
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Bricaud, O., and Collazo, A. (2011) Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. Developmental Biology. 357(1):191-201
- Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
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