Gene
c3a.1
- ID
- ZDB-GENE-990415-35
- Name
- complement C3a, tandem duplicate 1
- Symbol
- c3a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable endopeptidase inhibitor activity and serine-type endopeptidase activity. Acts upstream of or within chordate embryonic development and positive regulation of neutrophil migration. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb26 (3 images)
- IMAGE:7148060 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb800 | Allele with one delins | Intron 2 | Unknown | CRISPR | |
| ihb814 | Allele with one delins | Intron 2 | Unknown | not specified | |
| sa1745 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8557 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10419 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18656 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19621 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31241 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31242 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32790 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-c3a.1 | China Zebrafish Resource Center (CZRC) | |
| CRISPR2-c3a.1 | Zebrafish Nomenclature Committee | |
| MO1-c3a | N/A | Forn-Cuní et al., 2014 |
| MO1-c3a.1 | N/A | Forn-Cuní et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 9 | Alliance | {Macular degeneration, age-related, 9} | 611378 |
| complement component 3 deficiency | Alliance | C3 deficiency | 613779 |
| {Hemolytic uremic syndrome, atypical, susceptibility to, 5} | 612925 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019742 | Alpha-2-macroglobulin, conserved site |
| Conserved_site | IPR047565 | Alpha-macroglobulin-like, thiol-ester bond-forming region |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR035815 | Complement C3-like, NTR domain |
| Domain | IPR040839 | Macroglobulin domain MG4 |
| Domain | IPR041425 | Complement C3/4/5, macroglobulin domain MG1 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Domain | IPR048848 | Complement component 3, CUB domain, second segment |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-2-macroglobulin, conserved site | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Complement C3/4/5, macroglobulin domain MG1 | Complement C3-like, NTR domain | Complement component 3, CUB domain, second segment | Immunoglobulin-like fold | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P7C1 | InterPro | 1643 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-76B14 | ZFIN Curated Data | |
| Encodes | EST | cb26 | Thisse et al., 2001 | |
| Encodes | EST | fi34b03 | ||
| Encodes | EST | fj86e11 | ||
| Encodes | EST | IMAGE:7148060 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131242 (1) | 5079 nt | ||
| Genomic | GenBank:CU280887 (2) | 132186 nt | ||
| Polypeptide | UniProtKB:A0A8M1P7C1 (1) | 1643 aa |
- Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., Bao, B. (2024) Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology. 13(6):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Pereiro, P., Rey-Campos, M., Figueras, A., Novoa, B. (2023) An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Frontiers in immunology. 13:11000921100092
- Chen, X.K., Kwan, J.S., Wong, G.T., Yi, Z.N., Ma, A.C., Chang, R.C. (2022) Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 54(7):973-987
- He, B.W., Wang, F.F., Qu, L.P. (2022) Anti-Inflammatory and Antioxidant Properties of Physalis alkekengi L. Extracts In Vitro and In Vivo: Potential Application for Skin Care. Evidence-based complementary and alternative medicine : eCAM. 2022:7579572
- Lelieveld, L.T., Gerhardt, S., Maas, S., Zwiers, K.C., de Wit, C., Beijk, E.H., Ferraz, M.J., Artola, M., Meijer, A.H., Tudorache, C., Salvatori, D., Boot, R.G., Aerts, J.M.F.G. (2022) Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Journal of Lipid Research. 63(5):100199
- Sehring, I.M., Mohammadi, H.F., Haffner-Luntzer, M., Ignatius, A., Huber-Lang, M., Weidinger, G. (2022) Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. eLIFE. 11:
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
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