Gene
c3a.1
- ID
- ZDB-GENE-990415-35
- Name
- complement C3a, tandem duplicate 1
- Symbol
- c3a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable endopeptidase inhibitor activity and serine-type endopeptidase activity. Acts upstream of or within chordate embryonic development and positive regulation of neutrophil migration. Predicted to be located in extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb26 (3 images)
- IMAGE:7148060 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 9 | Alliance | {Macular degeneration, age-related, 9} | 611378 |
| complement component 3 deficiency | Alliance | C3 deficiency | 613779 |
| {Hemolytic uremic syndrome, atypical, susceptibility to, 5} | 612925 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019742 | Alpha-2-macroglobulin, conserved site |
| Conserved_site | IPR047565 | Alpha-macroglobulin-like, thiol-ester bond-forming region |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR035815 | Complement C3-like, NTR domain |
| Domain | IPR040839 | Macroglobulin domain MG4 |
| Domain | IPR041425 | Complement C3/4/5, macroglobulin domain MG1 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Domain | IPR048848 | Complement component 3, CUB domain, second segment |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-2-macroglobulin, conserved site | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Complement C3/4/5, macroglobulin domain MG1 | Complement C3-like, NTR domain | Complement component 3, CUB domain, second segment | Immunoglobulin-like fold | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P7C1 | InterPro | 1643 |
Interactions and Pathways
No data available
Plasmids
No data available