Gene

bfb

ID

ZDB-GENE-990415-34

Name

complement component bfb

Symbol

bfb Nomenclature History

Previous Names

Bf-2 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation and proteolysis. Predicted to be located in extracellular region. Predicted to be part of classical-complement-pathway C3/C5 convertase complex. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92519 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bfb Human Ortholog

No data available

Associated With bfb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR002035	von Willebrand factor, type A
Family	IPR011360	Complement B/C2
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily