Gene

itk

ID
ZDB-GENE-990415-261
Name
IL2 inducible T cell kinase
Symbol
itk Nomenclature History
Previous Names
  • Ptk
  • etID309877.14 (1)
  • tec
  • ZFPtk
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in adaptive immune response; antigen receptor-mediated signaling pathway; and peptidyl-tyrosine autophosphorylation. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Haire et al., 1998
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lymphoproliferative syndrome 1 Alliance Lymphoproliferative syndrome 1 613011
Associated With itk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001562 Zinc finger, Btk motif
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001452 SH3 domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Zinc finger, Btk motif
UniProtKB:A0A2R8QJ75 582
UniProtKB:O42200 616
UniProtKB:F1R3M1 616
UniProtKB:A0A140LG31 60
UniProtKB:A0A2R8RK79 603
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations