Gene
tap2c
- ID
- ZDB-GENE-990415-260
- Name
- transporter associated with antigen processing, subunit type c
- Symbol
- tap2c Nomenclature History
- Previous Names
-
- tap2 (1)
- abcb3
- si:dz179b20.3
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Is predicted to enable ABC-type peptide transporter activity and ATP binding activity. Acts upstream of or within response to methylmercury. Predicted to be located in lysosomal membrane. Predicted to be integral component of membrane. Is expressed in brain; liver; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
- Genome Resources
-
- Alliance (1)
- Gene:30695 (1)
- VEGA:OTTDARG00000001710 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Gonzalez et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MHC class I deficiency | Alliance | Bare lymphocyte syndrome, type I, due to TAP2 deficiency | 604571 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR030254 | ATP-binding cassette subfamily B member 9 |
| Family | IPR039421 | Type 1 protein exporter |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | ATP-binding cassette subfamily B member 9 | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AVZ9
|
700 | ||||||
|
UniProtKB:O57334
|
146 |
- Genome Browsers
- No data available
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance