Gene

tap2c

ID
ZDB-GENE-990415-260
Name
transporter associated with antigen processing, subunit type c
Symbol
tap2c Nomenclature History
Previous Names
  • tap2 (1)
  • abcb3
  • si:dz179b20.3
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Is predicted to enable ABC-type peptide transporter activity and ATP binding activity. Acts upstream of or within response to methylmercury. Predicted to be located in lysosomal membrane. Predicted to be integral component of membrane. Is expressed in brain; liver; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Gonzalez et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tap2c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
MHC class I deficiency Alliance Bare lymphocyte syndrome, type I, due to TAP2 deficiency 604571
Associated With tap2c Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Family IPR030254 ATP-binding cassette subfamily B member 9
Family IPR039421 Type 1 protein exporter
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily ATP-binding cassette subfamily B member 9 P-loop containing nucleoside triphosphate hydrolase Type 1 protein exporter
UniProtKB:Q8AVZ9 700
UniProtKB:O57334 146
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations