Gene
rx2
- ID
- ZDB-GENE-990415-237
- Name
- retinal homeobox gene 2
- Symbol
- rx2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in camera-type eye photoreceptor cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Is expressed in eye; immature eye; optic primordium; and presumptive diencephalon. Orthologous to human RAX (retina and anterior neural fold homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nelson et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, syndromic 16 | 611038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|
|
UniProtKB:O42357
|
327 | |||||
|
UniProtKB:F1QNV0
|
327 |
Interactions and Pathways
No data available
Plasmids
No data available