Gene

fzd5

ID
ZDB-GENE-990415-218
Name
frizzled class receptor 5
Symbol
fzd5 Nomenclature History
Previous Names
  • fz2
  • Fz5 (1)
  • fz8c (1)
  • fzd8c (1)
  • zg02 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits Wnt-activated receptor activity. Involved in animal organ development; negative regulation of canonical Wnt signaling pathway; and non-canonical Wnt signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Used to study coloboma. Orthologous to human FZD5 (frizzled class receptor 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fzd5 Human Ortholog
No data available
Associated With fzd5 Via Experimental Models
Human Disease Fish Conditions Citations
coloboma AB + MO3-fzd5 standard conditions Liu et al., 2016
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Domain IPR020067 Frizzled domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like
UniProtKB:B3DIG4 592
UniProtKB:Q90443 95
UniProtKB:Q9W6E2 592
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Momoi, et al. (2003. Mech. Dev. 120:477-489.) reported this gene as fz8c with orthology to human FZD8 and mouse Fzd8 based on amino acid similarity. Subsequent analysis suggests this gene is fzd5 with orthology to human FZD5 and mouse Fzd5 based on amino acid similarity and conserved location.
Citations