Gene

fzd4

ID
ZDB-GENE-990415-217
Name
frizzled class receptor 4
Symbol
fzd4 Nomenclature History
Previous Names
  • fz1
  • zg01
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within retina homeostasis and retina vasculature development in camera-type eye. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; neural plate; and neurogenic placode. Used to study exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Caceres et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fzd4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
exudative vitreoretinopathy 1 Alliance Exudative vitreoretinopathy 1 133780
exudative vitreoretinopathy 1 Alliance Retinopathy of prematurity 133780
1 - 2 of 2
Associated With fzd4 Via Experimental Models
Human Disease Fish Conditions Citations
exudative vitreoretinopathy fzd4zf3345/zf3345; y1Tg (AB) standard conditions Caceres et al., 2019
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, 7TM
Domain IPR017981 GPCR, family 2-like, 7TM
Domain IPR020067 Frizzled domain
Domain IPR026551 Frizzled-4, 7TM
Domain IPR041765 Frizzled 4, cysteine-rich domain
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length Frizzled-4, 7TM Frizzled 4, cysteine-rich domain Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, 7TM GPCR, family 2-like, 7TM
UniProtKB:A0A0R4IVK2 InterPro 523
1 - 1 of 1
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
No data available
Sequences
Orthology
Comparative Orthology
Alliance
Citations
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