Gene
pparab
- ID
- ZDB-GENE-990415-211
- Name
- peroxisome proliferator-activated receptor alpha b
- Symbol
- pparab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Involved in cellular response to cold and response to activity. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Is expressed in several structures, including digestive system; female organism; immature eye; nervous system; and spinal cord neural tube. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017618 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003074 | Peroxisome proliferator-activated receptor |
| Family | IPR003076 | Peroxisome proliferator-activated receptor alpha |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A6XMH7
|
459 | ||||||||
|
UniProtKB:K7DY57
|
459 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pparab-201
(1)
|
Ensembl | 1,590 nt | ||
| mRNA |
pparab-202
(1)
|
Ensembl | 1,418 nt |
Interactions and Pathways
No data available
Plasmids
No data available