Gene
prph
- ID
- ZDB-GENE-990415-207
- Name
- peripherin
- Symbol
- prph Nomenclature History
- Previous Names
-
- plasticin
- zgc:111926
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within tissue regeneration. Predicted to be located in intermediate filament. Predicted to be active in several cellular components, including axon; plasma membrane; and type III intermediate filament. Is expressed in nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la017851Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018039 | Intermediate filament protein, conserved site |
Domain | IPR006821 | Intermediate filament head, DNA-binding domain |
Domain | IPR039008 | Intermediate filament, rod domain |
Family | IPR002957 | Keratin, type I |
Family | IPR050405 | Intermediate filament structural protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Intermediate filament head, DNA-binding domain | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Intermediate filament structural protein | Keratin, type I |
---|---|---|---|---|---|---|---|
UniProtKB:Q502Q7 | InterPro | 442 | |||||
UniProtKB:A0A8M6Z374 | InterPro | 299 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-211D19 | ZFIN Curated Data | |
Contained in | Fosmid | ZFOS-221A11 | ZFIN Curated Data | |
Encodes | EST | af024598 | ||
Encodes | cDNA | MGC:111926 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131054 (1) | 2760 nt | ||
Genomic | GenBank:FO704600 (1) | 42387 nt | ||
Polypeptide | UniProtKB:Q502Q7 (1) | 442 aa |
- Ho, M., Thompson, B., Fisk, J.N., Nebert, D.W., Bruford, E.A., Vasiliou, V., Bunick, C.G. (2022) Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human genomics. 16:1
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Goto, H., Kimmey, S.C., Row, R.H., Matus, D.Q., Martin, B.L. (2017) FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step EMT. Development (Cambridge, England). 144(8):1412-1424
- Liao, M.L., Peng, W.H., Kan, D., Chien, C.L. (2016) Developmental Pattern of the Neuronal Intermediate Filament inaa in the Zebrafish Retina. The Journal of comparative neurology. 524(18):3810-3826
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wheeler, N.A., Lister, J.A., Fuss, B. (2015) The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:11399-414
- Kotkamp, K., Mössner, R., Allen, A., Onichtchouk, D., and Driever, W. (2014) A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis. Developmental Biology. 385(2):433-47
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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