ZFIN ID: ZDB-GENE-990415-198
Gene Name: teratocarcinoma-derived growth factor 1
Gene Symbol: tdgf1    Nomenclature History

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Previous Names: cb85 (1), cripto, oep, one eyed pinhead, one-eyed pinhead, wu:fe01d04, zgc:109829

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have activin receptor binding activity and nodal binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to the external side of plasma membrane. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer; congenital heart disease; and visceral heterotaxy. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1).
Genome Resources: Alliance (1),  Gene:30304 (1),  Ensembl(GRCz11):ENSDARG00000035095 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ko202 Point Mutation Exon 3 Premature Stop CRISPR
la017432Tg Transgenic Insertion Unknown Unknown DNA
m134 Point Mutation Unknown Premature Stop ENU
tdgf1_unspecified Unspecified Unknown Unknown
tz257 Point Mutation Start Codon Start Loss ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z1 Deficiency Unknown Unknown G_RAYS
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tdgf1 1
    CRISPR2-tdgf1
    1
    CRISPR3-tdgf1
    1
    MO1-tdgf1 N/A 11
    PHENOTYPE
    Data: 63 figures from 41 publications
    Observed in:
    DISEASE ASSOCIATED WITH tdgf1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Forebrain defects
    DISEASE ASSOCIATED WITH tdgf1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    neural tube defect tdgf1m134/m134 standard conditions Ma et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process floor plate formation (more)
    Cellular Component external side of plasma membrane (more)
    Molecular Function activin receptor binding (more)
    GO Terms (all 46)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR013032 EGF-like, conserved site
    Domain IPR019011 Cryptic/Cripto, CFC domain
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tdgf1 No data available
    MARKER RELATIONSHIPS
    tdgf1 Encodes: [EST] cb85 (1) (order this), fe01d04
    [cDNA] MGC:109829 (1), MGC:173598 (1), MGC:174150 (1), MGC:192394 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131092 (1) 1535 nt
    Genomic GenBank:CABZ01070743 (1) 6287 nt
    Polypeptide UniProtKB:F1Q691 (1) 190 aa
    Sequence Information (all 35)
    ORTHOLOGY for tdgf1 ( Chr: 10 )
    CITATIONS (285)