Gene
npy8ar
- ID
- ZDB-GENE-990415-175
- Name
- neuropeptide Y receptor Y8a
- Symbol
- npy8ar Nomenclature History
- Previous Names
-
- npyryc
- zgc:194694
- zgc:194705
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including digestive system; heart; immune system; nervous system; and notochord.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017588Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Neuropeptide Y receptor family |
|---|---|---|---|---|
|
UniProtKB:O73734
|
373 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npy8ar-201
(1)
|
Ensembl | 1,283 nt | ||
| mRNA |
npy8ar-202
(1)
|
Ensembl | 539 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-159H15 | ZFIN Curated Data | |
| Contained in | BAC | CH73-309F12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194694 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194705 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131437 (1) | 1122 nt | ||
| Genomic | GenBank:CT826389 (1) | 124788 nt | ||
| Polypeptide | UniProtKB:O73734 (1) | 373 aa |
No data available
- Singh, C., Rihel, J., Prober, D.A. (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current biology : CB. 27(24):3796-3811.e5
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Larhammar, D., and Bergqvist, C.A. (2013) Ancient Grandeur of the Vertebrate Neuropeptide Y System Shown by the Coelacanth Latimeria chalumnae. Frontiers in neuroscience. 7:27
- Sundström, G., Larsson, T.A., Xu, B., Heldin, J., and Larhammar, D. (2013) Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Frontiers in neuroscience. 7:29
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Larsson, T.A., Tay, B.H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B. (2009) Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics. 93(3):254-260
- Salaneck, E., Larsson, T.A., Larson, E.T., and Larhammar, D. (2008) Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization. Gene. 409(1-2):61-71
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Fredriksson, R., Sjodin, P., Larson, E.T., Conlon, J.M., and Larhammar, D. (2006) Cloning and characterization of a zebrafish Y2 receptor. Regulatory peptides. 133(1-3):32-40
- Larsson, T.A., Olsson, F., Sundström, G., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Pufferfish and Zebrafish Have Five Distinct NPY Receptor Subtypes, but Have Lost Appetite Receptors Y1 and Y5. Annals of the New York Academy of Sciences. 1040:375-377
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