Gene
isl2b
- ID
- ZDB-GENE-990415-133
- Name
- ISL LIM homeobox 2b
- Symbol
- isl2b Nomenclature History
- Previous Names
-
- isl3
- zfIsl-3
- zgc:109840
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within exocrine pancreas development and secondary heart field specification. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; anterior lateral plate mesoderm; nervous system; pancreas; and trigeminal placode. Orthologous to human ISL2 (ISL LIM homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109840 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Witzel et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-isl2b | Yan et al., 2023 | |
| MO1-isl2b | N/A | Wilfinger et al., 2013 |
| MO2-isl2b | N/A | Witzel et al., 2017 |
| TALEN1-isl2b | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047244 | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 |
| Family | IPR047169 | Insulin gene enhancer protein ISL-1/2-like |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:P53407 | InterPro | 358 | ||||||
| UniProtKB:A0A8M9QGM0 | InterPro | 256 |
Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-148P15 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-132M23 | ||
| Contains | SNP | rs3728066 | Stickney et al., 2002 | |
| Encodes | cDNA | MGC:109840 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130964 (1) | 1652 nt | ||
| Genomic | GenBank:AL845510 (2) | 101241 nt | ||
| Polypeptide | UniProtKB:P53407 (1) | 358 aa |
- Hammer, J., Röppenack, P., Yousuf, S., Machate, A., Fischer, M., Hans, S., Brand, M. (2024) Blind But Alive - Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish. Investigative ophthalmology & visual science. 65:4242
- Beckers, A., Masin, L., Van Dyck, A., Bergmans, S., Vanhunsel, S., Zhang, A., Verreet, T., Poulain, F.E., Farrow, K., Moons, L. (2023) Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics. Neural regeneration research. 18:219-225
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Yan, C.Y., Wu, F.Y., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Zhang, C.X., Wang, Z., Yang, R.M., Yang, L., Dong, M., Zhang, Q.Y., Ye, X.P., Song, H.D., Zhao, S.X. (2023) The isl2a transcription factor regulates pituitary development in zebrafish. Frontiers in endocrinology. 14:920548920548
- Jing, Y., Ren, Y., Witzel, H.R., Dobreva, G. (2021) A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Stem Cell Reports. 16(8):1894-1905
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- Spead, O., Weaver, C.J., Moreland, T., Poulain, F.E. (2021) Live imaging of retinotectal mapping reveals topographic map dynamics and a novel role for Contactin-2 in map sharpening. Development (Cambridge, England). 148(22)
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Wong, E.S., Zheng, D., Tan, S.Z., Bower, N.L., Garside, V., Vanwalleghem, G., Gaiti, F., Scott, E., Hogan, B.M., Kikuchi, K., McGlinn, E., Francois, M., Degnan, B.M. (2020) Deep conservation of the enhancer regulatory code in animals. Science (New York, N.Y.). 370(6517):
- Zhou, M., Bear, J., Roberts, P.A., Janiak, F.K., Semmelhack, J., Yoshimatsu, T., Baden, T. (2020) Zebrafish Retinal Ganglion Cells Asymmetrically Encode Spectral and Temporal Information across Visual Space. Current biology : CB. 30(15):2927-2942.e7
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