Gene
isl2b
- ID
- ZDB-GENE-990415-133
- Name
- ISL LIM homeobox 2b
- Symbol
- isl2b Nomenclature History
- Previous Names
-
- isl3
- zfIsl-3
- zgc:109840
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within exocrine pancreas development and secondary heart field specification. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; anterior lateral plate mesoderm; nervous system; pancreas; and trigeminal placode. Orthologous to human ISL2 (ISL LIM homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109840 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Witzel et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047244 | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 |
| Family | IPR047169 | Insulin gene enhancer protein ISL-1/2-like |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:P53407
|
358 | ||||||
|
UniProtKB:A0A8M9QGM0
|
256 |
Interactions and Pathways
No data available
Plasmids