Gene

htt

ID
ZDB-GENE-990415-131
Name
huntingtin
Symbol
htt Nomenclature History
Previous Names
  • etID309952.1 (1)
  • hd (1)
  • ZHD (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Involved in several processes, including chordate embryonic development; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to cytoplasm. Is expressed in brain; head; intermediate cell mass of mesoderm; and post-vent region. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htt Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Huntington's disease Alliance Huntington disease 143100
Lopes-Maciel-Rodan syndrome 617435
Associated With htt Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000091 Huntingtin
Family IPR028426 Huntingtin family
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR024613 Huntingtin, middle-repeat
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold Huntingtin Huntingtin family Huntingtin, middle-repeat
UniProtKB:B7ZDE9 3121
UniProtKB:Q78CP3 32
UniProtKB:O42269 3121
UniProtKB:Q78CQ8 130
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations