ZFIN ID: ZDB-GENE-990415-131
Gene Name: huntingtin
Gene Symbol: htt    Nomenclature History

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Previous Names: etID309952.1 (1), hd (1), ZHD (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in several processes, including chordate embryonic development; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to cytoplasm. Is expressed in brain; head; intermediate cell mass of mesoderm; and post-vent region. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (huntingtin).
Genome Resources: Alliance (1),  Gene:30214 (1),  Ensembl(GRCz11):ENSDARG00000052866 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12352 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15014 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19544 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19545 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38282 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39657 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39658 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39659 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45079 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko778a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko778b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-htt 1
    MO1-htt N/A 7
    MO2-htt N/A 4
    DISEASE ASSOCIATED WITH htt HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Huntington's disease Alliance Huntington disease 143100
    Lopes-Maciel-Rodan syndrome 617435
    DISEASE ASSOCIATED WITH htt VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Huntington's disease WT + MO1-htt standard conditions Conforti et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior neural plate formation (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    antisense ottdart00000041370 (1) 902
    mRNA htt-201 (1)    Ensembl 10780
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM htt No data available
    MARKER RELATIONSHIPS
    htt Contained in: [BAC] CH211-89O9 (1), DKEY-21K13 (1) (order this), DKEY-180B4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131018 (1) 10620 nt
    Genomic GenBank:BX511019 (1) 180744 nt
    Select Tool
    Polypeptide UniProtKB:B7ZDE9 (1) 3121 aa
    Sequence Information (all 27)
    ORTHOLOGY for htt ( Chr: 1 )
    CITATIONS (28)