ZFIN ID: ZDB-GENE-990415-105
Gene Name: homeobox B4a
Gene Symbol: hoxb4a    Nomenclature History

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Previous Names: hoxb4, etID309956.3 (1), sb:eu512, Z-17, ZF-13, zf13

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and activating transcription factor binding activity. Predicted to be involved in anterior/posterior pattern specification and embryonic skeletal system morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including hindbrain neural keel; nervous system; neural rod; pharyngeal arch; and somite. Orthologous to human HOXB4 (homeobox B4).
Genome Resources: Alliance (1),  Gene:30340 (1),  Ensembl(GRCz11):ENSDARG00000013533 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015135Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa997 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hoxb4a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hoxb4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hoxb4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hoxb4a-201 (1)    Ensembl 1235
    hoxb4a-202 (1)    Ensembl 529
    ottdart00000001816 (1) 1333
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM hoxb4a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.2hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(-4.5hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(-7.3hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(-7.7hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(-8.7hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(-11.3hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(1.9hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(3.2hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(hoxb4a:GFP) hoxb4a GFP Danio rerio 1 2
    Tg(lmo2:LOXP-DsRed-LOXP-hoxb4a-EGFP) lmo2 DsRedEGFPhoxb4aLOXP Danio rerio 1 1
    MARKER RELATIONSHIPS
    hoxb4a Contained in: [BAC] CH211-72A16 (1)
    [PAC] BUSM1-254O17 (2)
    hoxb4a Encodes: [EST] eu512 (1)
    [cDNA] MGC:194195 (1), MGC:194206 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131118 (1) 741 nt
    Genomic GenBank:BX927395 (1) 152987 nt
    Select Tool
    Polypeptide UniProtKB:B3DHP6 (1) 246 aa
    Sequence Information (all 28)
    ORTHOLOGY for hoxb4a ( Chr: 3 )
    CITATIONS (96)