Gene

ptpn1

ID

ZDB-GENE-980605-23

Name

protein tyrosine phosphatase non-receptor type 1

Symbol

ptpn1 Nomenclature History

Previous Names

PTP-1B (1)
ptp1b
fk54h03
wu:fk54h03

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in liver. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66113 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptpn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Insulin resistance, susceptibility to}	125853

Associated With ptpn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Family	IPR012265	Protein-tyrosine phosphatase, non-receptor type-1/2
Family	IPR051985	Non-receptor type tyrosine-specific phosphatase
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like

Domain Details Per Protein

Protein	Length	Non-receptor type tyrosine-specific phosphatase	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase, catalytic	Protein-tyrosine phosphatase-like	Protein-tyrosine phosphatase, non-receptor type-1/2	Tyrosine-specific protein phosphatase, PTPase domain	Tyrosine-specific protein phosphatases domain
UniProtKB:Q7ZWI6 InterPro	461
UniProtKB:Q9PT91 InterPro	433
UniProtKB:A0A8M1P706 InterPro	433

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ptpn1-201 (1) Ensembl	Ensembl		3,064 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations