Gene
ptpn1
- ID
- ZDB-GENE-980605-23
- Name
- protein tyrosine phosphatase non-receptor type 1
- Symbol
- ptpn1 Nomenclature History
- Previous Names
-
- PTP-1B (1)
- ptp1b
- fk54h03
- wu:fk54h03
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in liver. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66113 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type 2 diabetes mellitus | Alliance | {Insulin resistance, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
Family | IPR012265 | Protein-tyrosine phosphatase, non-receptor type-1/2 |
Family | IPR051985 | Non-receptor type tyrosine-specific phosphatase |
Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
Protein | Length | Non-receptor type tyrosine-specific phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-1/2 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q7ZWI6
|
461 | |||||||
UniProtKB:Q9PT91
|
433 | |||||||
UniProtKB:A0A8M1P706
|
433 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available