Gene

hbaa1

ID
ZDB-GENE-980526-79
Name
hemoglobin, alpha adult 1
Symbol
hbaa1 Nomenclature History
Previous Names
  • AA1
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to hypoxia. Predicted to localize to haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in eye; hematopoietic system; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBZ (hemoglobin subunit zeta).
Genome Resources
Note
None
Expression
All Expression Data
30 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hbaa1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alpha thalassemia Alliance Thalassemias, alpha- 604131
familial erythrocytosis 7 Alliance Erythrocytosis 7 617981
Heinz body anemia Alliance Heinz body anemias, alpha- 140700
hemoglobin H disease Alliance Hemoglobin H disease, nondeletional 613978
Methemoglobinemia, alpha type 617973
Associated With hbaa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000971 Globin
Family IPR002338 Haemoglobin, alpha-type
Family IPR002339 Haemoglobin, pi
Homologous_superfamily IPR009050 Globin-like superfamily
Homologous_superfamily IPR012292 Globin/Protoglobin
Domain Details Per Protein
Protein Length Globin Globin-like superfamily Globin/Protoglobin Haemoglobin, alpha-type Haemoglobin, pi
UniProtKB:Q803Z5 143
UniProtKB:Q7SZV9 143
UniProtKB:Q90487 143
UniProtKB:Q1JQ69 143
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations