Gene

klf1

ID
ZDB-GENE-980526-55
Name
Kruppel-like factor 1 (erythroid)
Symbol
klf1 Nomenclature History
Previous Names
  • klfd
  • zgc:194069
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of gene expression and primitive erythrocyte differentiation. Predicted to localize to nucleus. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With klf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital dyserythropoietic anemia type IV Alliance Dyserythropoietic anemia, congenital, type IV 613673
Blood group--Lutheran inhibitor 111150
[Hereditary persistence of fetal hemoglobin] 613566
Associated With klf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q90XE6 365
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations