Gene
klf1
- ID
- ZDB-GENE-980526-55
- Name
- Kruppel-like factor 1 (erythroid)
- Symbol
- klf1 Nomenclature History
- Previous Names
-
- klfd
- zgc:194069
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of gene expression and primitive erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IV | Alliance | Dyserythropoietic anemia, congenital, type IV | 613673 |
| Blood group--Lutheran inhibitor | 111150 | ||
| [Hereditary persistence of fetal hemoglobin] | 613566 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q90XE6
|
365 |
Interactions and Pathways
No data available
Plasmids
No data available