Gene
klf1
- ID
- ZDB-GENE-980526-55
- Name
- Kruppel like factor 1 (erythroid)
- Symbol
- klf1 Nomenclature History
- Previous Names
-
- klfd
- zgc:194069
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ regeneration; cardiac muscle tissue development; and sarcomere organization. Acts upstream of or within positive regulation of gene expression; primitive erythrocyte differentiation; and regulation of primitive erythrocyte differentiation. Located in chromatin. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; kidney; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IVa and congenital dyserythropoietic anemia type IVb. Orthologous to human KLF1 (KLF transcription factor 1); KLF17 (KLF transcription factor 17); and KLF18 (KLF transcription factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IVa | Alliance | Anemia, dyserythropoietic congenital, type IVa | 613673 |
| congenital dyserythropoietic anemia type IVb | Alliance | Anemia, congenital dyserythropoietic, type IVb | 620969 |
| Blood group--Lutheran inhibitor | 111150 | ||
| [Hereditary persistence of fetal hemoglobin] | 613566 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:Q90XE6 | InterPro | 365 |
Interactions and Pathways
No data available
Plasmids
No data available