Gene

klf1

ID

ZDB-GENE-980526-55

Name

Kruppel like factor 1 (erythroid)

Symbol

klf1 Nomenclature History

Previous Names

klfd
zgc:194069

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ regeneration; cardiac muscle tissue development; and sarcomere organization. Acts upstream of or within positive regulation of gene expression; primitive erythrocyte differentiation; and regulation of primitive erythrocyte differentiation. Located in chromatin. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; kidney; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IVa and congenital dyserythropoietic anemia type IVb. Orthologous to human KLF1 (KLF transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu650 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With klf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital dyserythropoietic anemia type IVa	Alliance	Anemia, dyserythropoietic congenital, type IVa	613673
congenital dyserythropoietic anemia type IVb	Alliance	Anemia, congenital dyserythropoietic, type IVb	620969
		Blood group--Lutheran inhibitor	111150
		[Hereditary persistence of fetal hemoglobin]	613566

Associated With klf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:Q90XE6 InterPro	365

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	klf1-201 (1) Ensembl	Ensembl		2,525 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations