Gene
acvr2ba
- ID
- ZDB-GENE-980526-549
- Name
- activin A receptor type 2Ba
- Symbol
- acvr2ba Nomenclature History
- Previous Names
-
- actr2b
- actrIIb
- acvr2b
- wu:fj97d11
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have activin binding activity and activin-activated receptor activity. Involved in cartilage development; hindbrain development; and neural crest cell migration. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in several structures, including blastomere; central nervous system; digestive system; gonad; and oral epithelium. Orthologous to human ACVR2B (activin A receptor type 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113962 (1 image)
- eu356 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Albertson et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| visceral heterotaxy | Alliance | Heterotaxy, visceral, 4, autosomal | 613751 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9YGU4
|
509 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acvr2ba-201
(1)
|
Ensembl | 1,470 nt | ||
| mRNA |
acvr2ba-202
(1)
|
Ensembl | 1,530 nt | ||
| mRNA |
acvr2ba-203
(1)
|
Ensembl | 674 nt |
Interactions and Pathways
Plasmids