Gene

msx2b

ID
ZDB-GENE-980526-492
Name
muscle segment homeobox 2b
Symbol
msx2b Nomenclature History
Previous Names
  • msh-D
  • mshD
  • msxd (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including fin bud; median fin fold; sensory system; solid lens vesicle; and vent. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; parietal foramina; tooth and nail syndrome; and tooth disease (multiple). Orthologous to several human genes including MSX2 (msh homeobox 2).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msx2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniosynostosis Alliance Craniosynostosis 2 604757
parietal foramina Alliance Parietal foramina 1 168500
Parietal foramina with cleidocranial dysplasia 168550
Associated With msx2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q01704 226
UniProtKB:A0A0J9YJK2 241
UniProtKB:Q32LX2 226
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations