Gene
jak2a
- ID
- ZDB-GENE-980526-481
- Name
- Janus kinase 2a
- Symbol
- jak2a Nomenclature History
- Previous Names
-
- Jak2a kinase
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of receptor signaling pathway via JAK-STAT; and receptor signaling pathway via JAK-STAT. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Is expressed in several structures, including cardiovascular system; erythroblast; hematopoietic system; nervous system; and yolk. Orthologous to human JAK2 (Janus kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ma et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| Budd-Chiari syndrome | Alliance | {Budd-Chiari syndrome, somatic} | 600880 |
| essential thrombocythemia | Alliance | Thrombocythemia 3 | 614521 |
| familial erythrocytosis 1 | Alliance | Erythrocytosis, somatic | 133100 |
| myelofibrosis | Alliance | Myelofibrosis, somatic | 254450 |
| polycythemia vera | Alliance | Polycythemia vera, somatic | 263300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035589 | Janus kinase 2, catalytic domain |
| Domain | IPR035860 | Tyrosine-protein kinase JAK2, SH2 domain |
| Domain | IPR037838 | JAK2, FERM domain C-lobe |
| Domain | IPR041046 | JAK, FERM F2 lobe domain |
| Domain | IPR041155 | FERM F1 lobe ubiquitin-like domain |
| Domain | IPR041381 | JAK1-3/TYK2, pleckstrin homology-like domain |
| Family | IPR016251 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
| Family | IPR051286 | Janus Kinase (JAK) |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK2, FERM domain C-lobe | JAK, FERM F2 lobe domain | Janus kinase 2, catalytic domain | Janus Kinase (JAK) | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase JAK2, SH2 domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O93596
|
1095 | |||||||||||||||||||||
|
UniProtKB:F1QWX8
|
1095 |
Interactions and Pathways
Plasmids
No data available