ZFIN ID: ZDB-GENE-980526-481
Gene Name: Janus kinase 2a
Gene Symbol: jak2a    Nomenclature History

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Previous Name: Jak2a kinase

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of receptor signaling pathway via JAK-STAT; and receptor signaling pathway via JAK-STAT. Predicted to localize to cytoskeleton and membrane. Is expressed in several structures, including cardiovascular system; erythroblast; hematopoietic system; nervous system; and yolk. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Orthologous to human JAK2 (Janus kinase 2).
Genome Resources: Alliance (1),  Gene:30307 (1),  Ensembl(GRCz11):ENSDARG00000104808 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021886Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14232 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37192 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-jak2a
    1
    CRISPR2-jak2a
    1
    MO1-jak2a N/A 1
    MO2-jak2a N/A 1
    MO3-jak2a N/A 1
    TALEN1-jak2a
    1
    TALEN2-jak2a
    1
    TALEN3-jak2a
    1
    TALEN4-jak2a
    1
    TALEN5-jak2a
    1
    TALEN6-jak2a
    1
    DISEASE ASSOCIATED WITH jak2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    Budd-Chiari syndrome Alliance {Budd-Chiari syndrome, somatic} 600880
    essential thrombocythemia Alliance Thrombocythemia 3 614521
    familial erythrocytosis 1 Alliance Erythrocytosis, somatic 133100
    myelofibrosis Alliance Myelofibrosis, somatic 254450
    polycythemia vera Alliance Polycythemia vera, somatic 263300
    DISEASE ASSOCIATED WITH jak2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of receptor signaling pathway via JAK-STAT (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jak2a-203 (1)    Ensembl 4315
    ncRNA jak2a-002 (1)    Ensembl 579
    jak2a-003 (1)    Ensembl 656
    jak2a-004 (1)    Ensembl 607
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM jak2a No data available
    MARKER RELATIONSHIPS
    jak2a Contained in: [Fosmid] ZFOS-1462C8 (1)
    jak2a Encodes: [cDNA] MGC:193868 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131093 (1) 4387 nt
    Genomic GenBank:CU694470 (1) 41108 nt
    Select Tool
    Polypeptide UniProtKB:F1QWX8 (1) 1095 aa
    Sequence Information (all 16)
    ORTHOLOGY for jak2a ( Chr: 21 )
    CITATIONS (54)