ZFIN ID: ZDB-GENE-980526-481
Gene Name: Janus kinase 2a
Gene Symbol: jak2a    Nomenclature History

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Previous Name: Jak2a kinase

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of receptor signaling pathway via JAK-STAT; and receptor signaling pathway via JAK-STAT. Predicted to localize to the cytoskeleton and membrane. Human ortholog(s) of this gene implicated in several diseases, including Budd-Chiari syndrome; ankylosing spondylitis; familial erythrocytosis 1; hematologic cancer (multiple); and inflammatory bowel disease (multiple). Is expressed in several structures, including cardiovascular system; erythroblast; hematopoietic system; nervous system; and yolk. Orthologous to human JAK2 (Janus kinase 2).
Genome Resources: Alliance (1),  Gene:30307 (1),  Ensembl(GRCz11):ENSDARG00000104808 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021886Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14232 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37192 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-jak2a
    1
    CRISPR2-jak2a
    1
    MO1-jak2a N/A 1
    MO2-jak2a N/A 1
    MO3-jak2a N/A 1
    TALEN1-jak2a
    1
    TALEN2-jak2a
    1
    TALEN3-jak2a
    1
    TALEN4-jak2a
    1
    TALEN5-jak2a
    1
    TALEN6-jak2a
    1
    DISEASE ASSOCIATED WITH jak2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    Budd-Chiari syndrome Alliance {Budd-Chiari syndrome, somatic} 600880
    essential thrombocythemia Alliance Thrombocythemia 3 614521
    familial erythrocytosis 1 Alliance Erythrocytosis, somatic 133100
    myelofibrosis Alliance Myelofibrosis, somatic 254450
    polycythemia vera Alliance Polycythemia vera, somatic 263300
    DISEASE ASSOCIATED WITH jak2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of receptor signaling pathway via JAK-STAT (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000299 FERM domain
    Domain IPR000719 Protein kinase domain
    Domain IPR000980 SH2 domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Family IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR019749 Band 4.1 domain
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR035589 Janus kinase 2, catalytic domain
    Domain IPR035860 Tyrosine-protein kinase JAK2, SH2 domain
    Homologous_superfamily IPR035963 FERM superfamily, second domain
    Homologous_superfamily IPR036860 SH2 domain superfamily
    Domain IPR037838 JAK2, FERM domain C-lobe
    Domain IPR041046 JAK, FERM F2 lobe domain
    Domain IPR041155 FERM F1 lobe ubiquitin-like domain
    Domain IPR041381 Jak1, pleckstrin homology-like domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jak2a-203 (1)    Ensembl 4315
    ncRNA jak2a-002 (1)    Ensembl 579
    jak2a-003 (1)    Ensembl 656
    jak2a-004 (1)    Ensembl 607
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM jak2a No data available
    MARKER RELATIONSHIPS
    jak2a Contained in: [Fosmid] ZFOS-1462C8 (1)
    jak2a Encodes: [cDNA] MGC:193868 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131093 (1) 4387 bp
    Genomic GenBank:CU694470 (1) 41108 bp
    Select Tool
    Polypeptide UniProtKB:F1QWX8 (1) 1095 aa
    Sequence Clusters UniGene:4151 (1)
    Sequence Information (all 17)
    ORTHOLOGY for jak2a ( Chr: 21 )
    CITATIONS (54)