Gene
pax9
- ID
- ZDB-GENE-980526-399
- Name
- paired box 9
- Symbol
- pax9 Nomenclature History
- Previous Names
-
- etID309776.17 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within defense response to Gram-positive bacterium; regulation of neutrophil differentiation; and roof of mouth development. Predicted to be located in nucleus. Is expressed in several structures, including axial blood vessel; digestive system; hematopoietic system; oral ectoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human PAX9 (paired box 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu604 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pax9 | N/A | (4) |
| MO2-pax9 | N/A | Chen et al., 2014 |
| MO3-pax9 | N/A | Chen et al., 2014 |
| MO4-pax9 | N/A | Chen et al., 2015 |
| MO5-pax9 | N/A | Chen et al., 2015 |
| MO6-pax9 | N/A | Chen et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| tooth agenesis | Alliance | Tooth agenesis, selective, 3 | 604625 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q98865 | InterPro | 343 | |||||
| UniProtKB:Q98866 | InterPro | 270 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-34N18 | ZFIN Curated Data | |
| Encodes | EST | eu604 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:91793 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131298 (1) | 1939 nt | ||
| Genomic | GenBank:BX511145 (1) | 102544 nt | ||
| Polypeptide | UniProtKB:Q98865 (1) | 343 aa |
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Paudel, S., Gjorcheska, S., Bump, P., Barske, L. (2022) Patterning of cartilaginous condensations in the developing facial skeleton. Developmental Biology. 486:44-55
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Pak, B., Schmitt, C.E., Oh, S., Kim, J.D., Choi, W., Han, O., Kim, M., Kim, M.J., Ham, H.J., Kim, S., Huh, T.L., Kim, J.I., Jin, S.W. (2020) Pax9 is essential for granulopoiesis but dispensable for erythropoiesis in zebrafish. Biochemical and Biophysical Research Communications. 534:359-366
- Bickers, C., Española, S.D., Grainger, S., Pouget, C., Traver, D. (2018) Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 13:e0202747
- Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775
- Yuan, Q., Zhao, M., Tandon, B., Maili, L., Liu, X., Zhang, A., Baugh, E.H., Tran, T., Silva, R.M., Hecht, J.T., Swindell, E.C., Wagner, D.S., Letra, A. (2017) Role of WNT10A in failure of tooth development in humans and zebrafish. Molecular genetics & genomic medicine. 5:730-741
- Hulsey, C.D., Fraser, G.J., Meyer, A. (2016) Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions. Integrative and Comparative Biology. 56(3):373-88
- Chen, H., Beasley, A., Hu, Y., Chen, X. (2015) A Zebrafish Model for Studies on Esophageal Epithelial Biology. PLoS One. 10:e0143878
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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