ZFIN ID: ZDB-GENE-980526-389
Gene Name: growth differentiation factor 3
Gene Symbol: gdf3    Nomenclature History

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Previous Names: cb556 (1), dvr1, vg1 (2), zDVR-1, zDVR1, zgc:103542

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Involved in several processes, including embryonic morphogenesis; regulation of nodal signaling pathway involved in determination of left/right asymmetry; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome; dextro-looped transposition of the great arteries 3; isolated microphthalmia 7; and visceral heterotaxy. Is expressed in several structures, including heart primordium; mesoderm; oocyte; somite; and tail bud. Orthologous to several human genes including GDF3 (growth differentiation factor 3).
Genome Resources: Alliance (1),  Gene:30125 (1),  Ensembl(GRCz11):ENSDARG00000037995 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a164 Small Deletion Exon 1 Unknown CRISPR
a165 Small Deletion Exon 1 Unknown CRISPR
fb20a Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
pr05 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
pr06 Indel Unknown Unknown CRISPR
pr11 Indel Exon 1 Frameshift, Premature Stop CRISPR
sa22982 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zy51 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zy52 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zy53 Small Deletion Unknown Inframe Deletion TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gdf3 1
    CRISPR2-gdf3 2
    CRISPR3-gdf3 1
    MO1-gdf3 N/A 1
    MO2-gdf3 N/A 4
    MO3-gdf3 N/A 1
    MO4-gdf3 N/A 1
    MO5-gdf3 N/A 1
    TALEN1-gdf3 1
    PHENOTYPE
    Data: 22 figures from 8 publications
    Observed in:
    DISEASE ASSOCIATED WITH gdf3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated microphthalmia 7 Alliance Microphthalmia, isolated 7 613704
    Klippel-Feil syndrome 3 Alliance Klippel-Feil syndrome 3, autosomal dominant 613702
    Microphthalmia with coloboma 6 613703
    DISEASE ASSOCIATED WITH gdf3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component protein-containing complex (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR015615 Transforming growth factor-beta-related
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gdf3-201 (1)    Ensembl 1255
    gdf3-202 (1)    Ensembl 1519
    gdf3-203 (1)    Ensembl 803
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf3 No data available
    MARKER RELATIONSHIPS
    gdf3 Contained in: [Fosmid] ZFOS-1139C7 (1)
    gdf3 Encodes: [EST] cb556 (1) (order this)
    [cDNA] MGC:103542 (1), MGC:191347 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130948 (1) 1243 bp
    Genomic GenBank:FP101972 (1) 25835 bp
    Select Tool
    Polypeptide UniProtKB:P35621 (1) 355 aa
    Sequence Information (all 27)
    ORTHOLOGY for gdf3 ( Chr: 17 )
    CITATIONS (53)