Gene

gdf3

ID
ZDB-GENE-980526-389
Name
growth differentiation factor 3
Symbol
gdf3 Nomenclature History
Previous Names
  • cb556 (1)
  • dvr1
  • vg1 (2)
  • zDVR-1
  • zDVR1
  • zgc:103542
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have cytokine activity. Involved in several processes, including embryonic morphogenesis; regulation of nodal signaling pathway involved in determination of left/right asymmetry; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to protein-containing complex. Is expressed in several structures, including heart primordium; mesoderm; oocyte; somite; and tail bud. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 3; dextro-looped transposition of the great arteries 3; isolated microphthalmia 7; and visceral heterotaxy. Orthologous to several human genes including GDF3 (growth differentiation factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gdf3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 7 Alliance Microphthalmia, isolated 7 613704
Klippel-Feil syndrome 3 Alliance Klippel-Feil syndrome 3, autosomal dominant 613702
Microphthalmia with coloboma 6 613703
Associated With gdf3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:K7DYL7 301
UniProtKB:K7DY39 145
UniProtKB:P35621 355
UniProtKB:Q5RKN7 355
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations