Gene

bmp2a

ID
ZDB-GENE-980526-388
Name
bone morphogenetic protein 2a
Symbol
bmp2a Nomenclature History
Previous Names
  • bmp2
  • wu:fc59d09
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have BMP receptor binding activity and cytokine activity. Involved in positive regulation of BMP signaling pathway. Predicted to localize to extracellular space. Is expressed in several structures, including brain; digestive system; fin; mesoderm; and visual system. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).
Genome Resources
Note
None
Expression
All Expression Data
30 figures from 22 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmp2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type A2 Alliance Brachydactyly, type A2 112600
hemochromatosis type 1 Alliance {HFE hemochromatosis, modifier of} 235200
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 617877
Associated With bmp2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:O13109 386
UniProtKB:B3DI86 386
UniProtKB:A0A0B5GTK3 386
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations