Gene

tgfbr2b

ID
ZDB-GENE-980526-375
Name
transforming growth factor beta receptor 2b
Symbol
tgfbr2b Nomenclature History
Previous Names
  • tgfbr2
  • cb537 (1)
  • TGF-beta receptor 2
  • wu:fj05c10
  • zgc:110498 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in membrane raft. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Monteiro et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tgfbr2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
esophageal cancer Alliance Esophageal cancer, somatic 133239
hereditary nonpolyposis colorectal cancer type 6 Alliance Colorectal cancer, hereditary nonpolyposis, type 6 614331
Loeys-Dietz syndrome 2 Alliance Loeys-Dietz syndrome 2 610168
Associated With tgfbr2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR015013 Transforming growth factor beta receptor 2 ectodomain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Family IPR017194 Transforming growth factor-beta receptor, type II
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ser/Thr protein kinase, TGFB receptor Transforming growth factor beta receptor 2 ectodomain Transforming growth factor-beta receptor, type II
UniProtKB:F1QKF4 556
UniProtKB:Q7ZZU8 556
UniProtKB:Q58EQ1 556
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations