Gene

msx1a

ID
ZDB-GENE-980526-312
Name
muscle segment homeobox 1a
Symbol
msx1a Nomenclature History
Previous Names
  • msh-E
  • mshE
  • msx1 (1)
  • msxe (1)
  • cb435 (1)
  • id:ibd5099
  • zgc:111928
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in otic placode formation. Predicted to localize to nucleus. Is expressed in several structures, including immature eye; nervous system; neural keel; pharyngeal arch; and regenerating fin. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1).
Genome Resources
Note
None
Expression
All Expression Data
30 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msx1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 5 Alliance Orofacial cleft 5 608874
tooth agenesis Alliance Tooth agenesis, selective, 1, with or without orofacial cleft 106600
tooth and nail syndrome Alliance Ectodermal dysplasia 3, Witkop type 189500
Associated With msx1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q502Q5 156
UniProtKB:B3DG59 233
UniProtKB:Q90455 233
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations