Gene
mhc2daa
- ID
- ZDB-GENE-980526-201
- Name
- major histocompatibility complex class II DAA gene
- Symbol
- mhc2daa Nomenclature History
- Previous Names
-
- DAA
- mhc2a
- mhc2d8.37a3 (1)
- mhcdaa
- a4
- fj17g12
- si:busm1-266f07.2
- si:dz266f07.2
- si:zfos-2070c2.4
- wu:fa93a04
- wu:fj17g12
- zgc:103599
- zgc:113853
- zgc:113912
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hematologic cancer (multiple); liver disease (multiple); and systemic scleroderma (multiple). Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha); HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1); and HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2).
- Genome Resources
- Note
-
novel MHCII alpha chain protein
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR001003 | MHC class II, alpha chain, N-terminal |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR050160 | Major Histocompatibility Complex/Immunoglobulin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Major Histocompatibility Complex/Immunoglobulin | MHC classes I/II-like antigen recognition protein | MHC class II, alpha/beta chain, N-terminal | MHC class II, alpha chain, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1MTC7 | InterPro | 236 | |||||||||
| UniProtKB:Q4KM20 | InterPro | 236 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | si:busm1-266f07.2-001 (1) | Havana | 2,111 nt | ||
| mRNA |
si:busm1-266f07.2-201
(1)
|
Ensembl | 1,590 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | PAC | BUSM1-266F07 | ZFIN Curated Data | |
| Encodes | EST | eu793 | Thisse et al., 2005 | |
| Encodes | EST | fa93a04 | ZFIN Curated Data | |
| Encodes | EST | fj17g12 | ||
| Encodes | cDNA | MGC:103599 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113853 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113912 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192244 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004521 (1) | 2096 nt | ||
| Genomic | GenBank:CU694380 (1) | 142726 nt | ||
| Polypeptide | UniProtKB:Q1MTC7 (2) | 236 aa |
No data available
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Dijkstra, J.M., Yamaguchi, T. (2018) Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Immunogenetics. 71(3):233-249
- Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726
- Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2015) First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 10:e0126378
- Zoccola, E., Delamare-Deboutteville, J., Barnes, A.C. (2015) Identification of Barramundi (Lates calcarifer) DC-SCRIPT, a Specific Molecular Marker for Dendritic Cells in Fish. PLoS One. 10:e0132687
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