ZFIN ID: ZDB-GENE-980526-18
Gene Name: distal-less homeobox 2b
Gene Symbol: dlx2b    Nomenclature History

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Previous Name: dlx5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Is expressed in several structures, including dental epithelium; dental mesenchyme; forebrain; parasphenoid; and splanchnocranium. Orthologous to human DLX2 (distal-less homeobox 2).
Genome Resources: Alliance (1),  Gene:30557 (1),  Ensembl(GRCz11):ENSDARG00000017174 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013621Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021112Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko590a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dlx2b 1
    MO1-dlx2b N/A 4
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dlx2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dlx2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000047 Helix-turn-helix motif
    Domain IPR001356 Homeobox domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR020479 Homeobox domain, metazoa
    Domain IPR022135 Distal-less-like homeobox protein, N-terminal domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlx2b-201 (1)    Ensembl 1521
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(dlx2b-actb2:EGFP,myl7:GFP) actb2dlx2bmyl7 EGFPGFP Danio rerio 1 1
    Tg(dlx2b:EGFP) dlx2b EGFP Danio rerio 1 7
    Tg(dlx2b:GFP) dlx2b GFP Danio rerio 2 3
    MARKER RELATIONSHIPS
    dlx2b Contained in: [BAC] DKEY-18J14 (1) (order this)
    dlx2b Encodes: [EST] eu649 (1)
    [cDNA] MGC:162123 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131297 (1) 1526 bp
    Genomic GenBank:BX548015 (1) 255582 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A4IG28 (1) 276 aa
    Sequence Information (all 13)
    ORTHOLOGY for dlx2b ( Chr: 1 )
    CITATIONS (70)