Gene
jak2b
- ID
- ZDB-GENE-980526-123
- Name
- Janus kinase 2b
- Symbol
- jak2b Nomenclature History
- Previous Names
-
- Jak2b kinase
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; histone binding activity; and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in erythrocyte differentiation. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Is expressed in several structures, including lateral line; lens; mandibular arch skeleton; pronephric duct; and solid lens vesicle. Orthologous to human JAK2 (Janus kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| Budd-Chiari syndrome | Alliance | {Budd-Chiari syndrome, somatic} | 600880 |
| essential thrombocythemia | Alliance | Thrombocythemia 3 | 614521 |
| familial erythrocytosis 1 | Alliance | Erythrocytosis, somatic | 133100 |
| myelofibrosis | Alliance | Myelofibrosis, somatic | 254450 |
| polycythemia vera | Alliance | Polycythemia vera, somatic | 263300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035860 | Tyrosine-protein kinase JAK2, SH2 domain |
| Domain | IPR037838 | JAK2, FERM domain C-lobe |
| Domain | IPR041046 | JAK, FERM F2 lobe domain |
| Domain | IPR041155 | FERM F1 lobe ubiquitin-like domain |
| Domain | IPR041381 | JAK1-3/TYK2, pleckstrin homology-like domain |
| Family | IPR016251 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
| Family | IPR051286 | Janus Kinase (JAK) |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK2, FERM domain C-lobe | JAK, FERM F2 lobe domain | Janus Kinase (JAK) | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase JAK2, SH2 domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z6T4
|
954 | ||||||||||||||||||||
|
UniProtKB:C0RW38
|
1126 |
Interactions and Pathways
No data available
Plasmids
No data available