casp21

ID

ZDB-GENE-190425-1

Name

caspase 21, apoptosis-related cysteine peptidase

Symbol

casp21 Nomenclature History

Previous Names

casp7l (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cysteine-type endopeptidase activity and enzyme activator activity. Predicted to be involved in several processes, including erythrocyte differentiation; keratinocyte differentiation; and positive regulation of neuron apoptotic process. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in cranial blood vessel; intestinal bulb; muscle cell; nervous system; and pharyngeal arch.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Spead et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With casp21 Human Ortholog

No data available

Associated With casp21 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Family	IPR052039	Caspase-related proteases and regulators
Homologous_superfamily	IPR029030	Caspase-like domain superfamily