Gene
foxl2b
- ID
- ZDB-GENE-170803-1
- Name
- forkhead box L2b
- Symbol
- foxl2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within fourth ventricle development; maintenance of animal organ identity; and midbrain-hindbrain boundary development. Predicted to be located in nucleus. Is expressed in blood vessel; gonad; paraxial mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blepharophimosis, ptosis, and epicanthus inversus syndrome | Alliance | Blepharophimosis, epicanthus inversus, and ptosis, type 1 | 110100 |
| blepharophimosis, ptosis, and epicanthus inversus syndrome | Alliance | Blepharophimosis, epicanthus inversus, and ptosis, type 2 | 110100 |
| primary ovarian insufficiency 3 | Alliance | Premature ovarian failure 3 | 608996 |
1 - 3 of 3
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047515 | Forkhead box protein L2, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
1 - 5 of 7 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein L2, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QJW8 | InterPro | 285 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxl2b-201
(1)
|
Ensembl | 1,265 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available