Gene

spock1

ID

ZDB-GENE-110428-1

Name

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

Symbol

spock1 Nomenclature History

Previous Names

si:dkey-201i24.6
zmp:0000000756

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from O'Brown et al., 2023

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from O'Brown et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spock1 Human Ortholog

No data available

Associated With spock1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR002350	Kazal domain
Domain	IPR019577	SPARC/Testican, calcium-binding domain
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036058	Kazal domain superfamily
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily

Domain Details Per Protein

Protein	Length	EF-hand domain pair	Kazal domain	Kazal domain superfamily	SPARC/Testican, calcium-binding domain	Thyroglobulin type-1	Thyroglobulin type-1 superfamily
UniProtKB:A0A0G2L032 InterPro
UniProtKB:A0A0G2KM32 InterPro
UniProtKB:E7F9M2 InterPro	355

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	spock1-201 (1) Ensembl	Ensembl	1,567 nt	Select Tool ZFIN BLAST
mRNA	spock1-202 (1) Ensembl	Ensembl	271 nt	Select Tool ZFIN BLAST
mRNA	spock1-203 (1) Ensembl	Ensembl	1,934 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations