Gene

mafb

ID

ZDB-GENE-141211-38

Name

MAF bZIP transcription factor b

Symbol

mafb Nomenclature History

Previous Names

si:ch73-337g9.1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Is expressed in blood; brain; kidney; and spleen. Orthologous to human MAF (MAF bZIP transcription factor).

Genome Resources

Note

This gene, the ortholog and one of the zebrafish genome duplicates of the human MAF gene, has the same gene symbol as a different human gene (MAFB). This zebrafish mafb gene is not the ortholog of human MAFB. The identical gene symbol for non-orthologous genes is due to the genome duplicate naming conventions of the zebrafish nomenclature guidelines. The zebrafish orthologs of the human MAFB gene are mafba (ZDB-GENE-980526-515) and mafbb (ZDB-GENE-010605-4).

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mafb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ayme-Gripp syndrome	Alliance	Ayme-Gripp syndrome	601088
cataract 21 multiple types	Alliance	Cataract 21, multiple types	610202

Associated With mafb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004826	Basic leucine zipper domain, Maf-type
Domain	IPR004827	Basic-leucine zipper domain
Domain	IPR013592	Maf transcription factor, N-terminal
Family	IPR024874	Transcription factor Maf family
Homologous_superfamily	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily
Homologous_superfamily	IPR046347	Basic-leucine zipper domain superfamily