Gene

npr2

ID
ZDB-GENE-141030-2
Name
natriuretic peptide receptor 2
Symbol
npr2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; guanylate cyclase activity; and protein kinase activity. Involved in cardiac muscle cell proliferation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Is expressed in several structures, including fin; head; kidney; neural tube; and oocyte. Orthologous to human NPR2 (natriuretic peptide receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With npr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acromesomelic dysplasia, Maroteaux type Alliance Acromesomelic dysplasia 1, Maroteaux type 602875
Miura type epiphyseal chondrodysplasia Alliance Epiphyseal chondrodysplasia, Miura type 615923
Short stature with nonspecific skeletal abnormalities 616255
Associated With npr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001828 Receptor, ligand binding region
Family IPR001170 Adenylyl cyclase class-4/guanylyl cyclase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Homologous_superfamily IPR029787 Nucleotide cyclase
Domain Details Per Protein
Protein Length Adenylyl cyclase class-3/4/guanylyl cyclase Adenylyl cyclase class-4/guanylyl cyclase Adenylyl cyclase class-4/guanylyl cyclase, conserved site Nucleotide cyclase Periplasmic binding protein-like I Protein kinase domain Protein kinase-like domain superfamily Receptor, ligand binding region Serine-threonine/tyrosine-protein kinase, catalytic domain
UniProtKB:A0A0G2KGK2 1043
UniProtKB:D1LXJ2 148
UniProtKB:A0A2R8QJI9 1028
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-npr2 Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations