Gene

gfra1a

ID

ZDB-GENE-010226-2

Name

gdnf family receptor alpha 1a

Symbol

gfra1a Nomenclature History

Previous Names

zgc:110129
zmp:0000001075

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables MAP kinase kinase kinase activity. Acts upstream of or within enteric nervous system development and protein-containing complex assembly. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in nervous system; pleuroperitoneal region; presumptive enteric nervous system; and vagal neural crest. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Shepherd et al., 2004
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gfra1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Renal hypodysplasia/aplasia 4	619887

Associated With gfra1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR016017	GDNF/GAS1
Family	IPR003438	Glial cell line-derived neurotrophic factor receptor
Family	IPR003503	Glial cell line-derived neurotrophic factor receptor, alpha 1
Family	IPR017372	Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Homologous_superfamily	IPR037193	GDNF receptor alpha