Gene
cyp2x12
- ID
- ZDB-GENE-030131-4664
- Name
- cytochrome P450, family 2, subfamily X, polypeptide 12
- Symbol
- cyp2x12 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver.
- Genome Resources
- Note
-
There are alternate genes (haplotypes) in GRCz11: ENSDARG00000110311 and ENSDARG00000116677.
- Comparative Information
-
- All Expression Data
- 1 figure from Cheng et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8S079 | InterPro | 496 | |||||
| UniProtKB:A0A1L1QZC0 | InterPro | 496 | |||||
| UniProtKB:A0A8M9PY44 | InterPro | 496 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp2x12-202
(1)
|
Ensembl | 1,694 nt | ||
| ncRNA |
si:dkey-286h2.7-003
(1)
|
Ensembl | 946 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068222726 (1) | 2704 nt | ||
| Genomic | GenBank:CU179648 (1) | 188334 nt | ||
| Polypeptide | UniProtKB:A0A1L1QZC0 (1) | 496 aa |
No data available
- Mai, Y., Peng, S., Li, H., Lai, Z. (2019) Histological, biochemical and transcriptomic analyses reveal liver damage in zebrafish (Danio rerio) exposed to phenanthrene. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 225:108582
- Deng, S., Jia, P.P., Zhang, J.H., Junaid, M., Niu, A., Ma, Y.B., Fu, A., Pei, D.S. (2018) Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of hazardous materials. 357:146-158
- Chatzopoulou, A., Schoonheim, P.J., Torraca, V., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2017) Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. 447:61-70
- Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
- Tang, Y.M., Junaid, M., Niu, A., Deng, S., Pei, D.S. (2017) Diverse toxicological risks of PAHs in surface water with an impounding level of 175m in the Three Gorges Reservoir Area, China. The Science of the total environment. 580:1085-1096
- Cheng, W., Guo, L., Zhang, Z., Soo, H.M., Wen, C., Wu, W., and Peng, J. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology. 294(2):482-496
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