Gene

pelp1

ID

ZDB-GENE-140106-164

Name

proline, glutamate and leucine rich protein 1

Symbol

pelp1 Nomenclature History

Previous Names

zmp:0000001204 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to be involved in rRNA processing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa20939	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa31571	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With pelp1 Human Ortholog

No data available

Associated With pelp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012583	Pre-rRNA-processing protein RIX1, N-terminal
Domain	IPR012980	PELP1, middle domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Additional Resources	Length	Armadillo-like helical	Armadillo-type fold	PELP1, middle domain	Pre-rRNA-processing protein RIX1, N-terminal
UniProtKB:F1RE30	InterPro	1212

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 7

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pelp1-201 (1) Ensembl	Ensembl		4,095 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-6N21	BX005022	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001338982 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005022 (1)	217582 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:F1RE30 (1)	1212 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	PELP1	17	Ensembl:ENSG00000141456 Gene:27043 HGNC:30134 OMIM:609455	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Pelp1	11	Ensembl:ENSMUSG00000018921 Gene:75273 MGI:1922523	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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