Gene

akt1

ID
ZDB-GENE-130730-1
Name
v-akt murine thymoma viral oncogene homolog 1
Symbol
akt1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of neuron differentiation. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; Proteus syndrome; breast cancer (multiple); pancreatic cancer (multiple); and prostate cancer (multiple). Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Orthologous to human AKT1 (AKT serine/threonine kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Cheng et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With akt1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance Breast cancer, somatic 114480
colorectal cancer Alliance Colorectal cancer, somatic 114500
Cowden syndrome 6 Alliance Cowden syndrome 6 615109
ovarian cancer Alliance Ovarian cancer, somatic 167000
Proteus syndrome Alliance Proteus syndrome, somatic 176920
Associated With akt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR001849 Pleckstrin homology domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR039026 Protein Kinase B, pleckstrin homology domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein Kinase B, pleckstrin homology domain Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:M4MD44 474
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA akt1-201 (1) Ensembl 744 nt
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations